POLYMICROBIAL INFECTION IN CYSTIC FIBROSIS AND FUTURE PERSPECTIVES FOR IMPROVING MYCOBACTERIUM ABSCESSUS DRUG DISCOVERY

Polymicrobial infection in cystic fibrosis and future perspectives for improving Mycobacterium abscessus drug discovery

tillman 750m Abstract Polymicrobial communities inhabit the cystic fibrosis (CF) airway, whereby microbial interactions can occur.One prominent CF pathogen is Mycobacterium abscessus, whose treatment is largely unsuccessful.This creates a need to discover novel antimicrobial agents to treat M.abscessus, however the methods read more used within ant

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The role of prior assumptions in carbon budget calculations

Cumulative emissions budgets and net-zero emission target dates are often used to frame climate negotiations (Frame et al., 2014; Millar et al., 2016; Van Vuuren et al., 2016; Rogelj et al., 2015b; Matthews et al., 2012).However, their utility for near-term policy decisions is confounded by uncertainties in future negative emissions capacity (Fuss

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Enhancing intrusion detection systems: Innovative deep learning approaches using CNN, RNN, DBN and autoencoders for robust network security

The increasing sophistication of cyber threats poses significant challenges to network security.This makes effective intrusion detection system (IDS) more important than ever before.Conventional IDS methods, which often rely on signatures or rules it will struggle to keep up with its complex attacks and read more evolution.This thesis evaluates and

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